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Sirtris, a GSK Company, and 2009 winner of American Business Awards Best Overall Company of the Year—up to 100 employees, is developing small molecule drugs that target the sirtuins, a recently discovered family of seven enzymes associated with the aging process. Modulation of these enzymes offers the promise of drug discovery in multiple therapeutic areas.

Join an enthusiastic team in a growing drug discovery company. Sirtris Pharmaceuticals seeks a motivated and team-oriented individual who will be a key contributor to the overall success of the Pharmacology group. The Associate Director, Pharmacology will provide the overall strategic direction of the Pharmacology group as part of Sirtris’ ongoing drug discovery efforts in the Sirtuin area.

Primary responsibilities:

o Provide strong leadership and strategic direction to the Pharmacology team.
o Mentor and guide the team through hands on lab work and troubleshooting as required.
o Evaluate the mechanism of action and efficacy of novel Sirtuin agents in the areas of metabolic and inflammatory disease.
o Translate cell-based discovery through in vivo models into the clinic.
o Represent the Pharmacology team at Project Team Meetings demonstrating excellent presentation skills.


PhD in Pharmacology or related discipline and 8-10 years of experience in the pharmaceutical/biotech industry. Must have current and detailed knowledge of in vivo models and PK/PD relationships in metabolic and/or inflammatory disease. Seeking excellent supervisory skills with the ability to influence internal and external decision-making and proven track record of scientific rigor through publications, patents, and speaking engagements. Should enjoy working independently under general direction in a fast-paced environment. Must have strong oral and written communication skills.


Join Sirtris where we are creating revolutionary medicines for diseases of aging. We hope you will see this as a unique opportunity to work in a fun, collaborative, and creative environment with leading edge science.

To apply, please go to: http://sirtrispharma.com/careers-opportunities38.html

Sirtris, a GSK Company, 200 Technology Square, Cambridge, MA 02139



Sirtris will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Note to Employment Agencies: Please do not forward any agency resumes. Sirtris is not responsible for any fees related to resumes that are unsolicited.

• Location: Cambridge
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